Early in the morning of August 6, 1945, a US Air Force B-29 Superfortress, the Enola Gay, took off from its base in Tinian, near Guam, and headed for the city of Hiroshima in southern Japan.

It was carrying a 9,700-pound top-secret bomb named Little Boy. Its pilot was Paul W. Tibbets Jr., who led a crew of 12 men on a mission that would change the history of the world. Tibbets had named the plane after his mother.

Hiroshima had already been woken by several air-raid sirens that morning, which had proved to be false alarms.

So when the Enola Gay approached at 8:15 a.m., many thought it was a reconnaissance plane. But by the time the siren sounded, the first atomic bomb to be used in a war had already dropped.

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In a blinding flash, and with temperatures as hot as the sun, the bomb detonated. It destroyed a 5-mile radius, killing an estimated 80,000 people.

Tens of thousands more later died of radiation sickness and injuries.

Col. Paul Tibbets Jr. in the pilot's seat of the Enola Gay moments before taking off for the mission to drop the atomic bomb on Hiroshima, Japan. Richard Cannon/Us Air Force/The LIFE Picture Collection via Getty Images/Getty Images

The Enola Gay was 10 miles away when the blast went off, but it still felt the shockwaves. The crew recalled the jolt from the force of the explosion and said it was like coming under enemy fire.

Three days later a second, more powerful atomic bomb was dropped on the city of Nagasaki, and Japan surrendered, bringing World War II to an end.

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A debate has raged ever since over whether the US was right to launch the attacks.

Some have argued that the bombings were an inhumane targeting of civilians and that there were other options available.

Others contend that such devastation was necessary to force Japan's surrender and avoid a deadly military campaign through the Japanese mainland.

But how did the explosion weigh with the 12 men aboard the Enola Gay who dropped the bomb that day?

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Some of the crew of the Enola Gay, the B-29 plane from which the first atom bomb was dropped. Tibbets is second from left. Art Edger/NY Daily News Archive via Getty Images

Tibbets and other crew members maintained to the end of their lives that the bombing was necessary, saying it ultimately saved lives.

"I knew we did the right thing because when I knew we'd be doing that I thought, yes, we're going to kill a lot of people, but by God we're going to save a lot of lives," Tibbets told the writer Studs Terkel in a 2002 interview. "We won't have to invade [Japan]."

An aerial view of the mushroom cloud of smoke as it billowed 20,000 feet in the air following the detonation of the atomic bomb over Hiroshima on August 6, 1945. Time Life Pictures/US Army Air Force/The LIFE Picture Collection via Getty Images/Getty Images

The US military had calculated that an invasion of Japan could have cost millions of US and Japanese lives. So, the reasoning goes, the attacks were necessary as an overwhelming show of force to end the war.

As for the loss of civilian lives, Tibbets, who died in 2007, was unrepentant.

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"You're gonna kill innocent people at the same time, but we've never fought a damn war anywhere in the world where they didn't kill innocent people," he told Terkel.

"If the newspapers would just cut out the s---: 'You've killed so many civilians.' That's their tough luck for being there."

Some of the members later came to express regret and described being haunted by the destruction they caused.

"I pray no man will have to witness that sight again. Such a terrible waste, such a loss of life," Capt. Theodore van Kirk, the plane's navigator that day, told an interviewer in 2005. "We unleashed the first atomic bomb, and I hope there will never be another."

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He added: "I pray that we have learned a lesson for all time. But I'm not sure that we have."

To date, Hiroshima and Nagasaki are the only places to be targeted by a nuclear bomb in war.

Cold War treaties halting the proliferation of nuclear weapons have begun to unravel, however, lending fresh urgency to questions on the morality of nuclear conflict.

The creator of the atomic bomb himself, J. Robert Oppenheimer, was also plagued by the morality of creating such a deadly weapon – something that was most recently captured in Christopher Nolan's much-anticipated "Oppenheimer" feature film.

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After succesfully testing the bomb in the desert of Los Alamos, New Mexico, Oppenheimer famousy said: "I am become Death, the destroyer of worlds" –  a line from the 700-verse Hindu scripture, the Bhagavad Gita.

"We knew the world would not be the same. A few people laughed, a few people cried, most people were silent," he later said. 

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